- Di processo
- An immune-mediated etiology is advocated in which the cns is hit by different pathogen-driven (auto)immune responses. A dimensional view, taking into account the multifactorial origin of psychiatric disorders, should suggest neuro-inflammation as a possible shared substrate of different psychiatric phenotypes. The conference starts presenting the inflammatory hypothesis and its mechanism (E.G. The microglial activation; the hyperpermeability of bbb, etc).
- Professionali
- Pediatric acute-onset neuropsychiatric syndrome (pans) features a heterogeneous constellation of acute obsessive-compulsive disorder (ocd), eating restriction, cognitive, behavioral and/or affective symptoms, often followed by a chronic course with cognitive deterioration.
- Di sistema
- The second part is focused on pans and discusses the clinical (ie, diagnostic criteria, pre-existing neurodevelopmental disorders, neuroimaging), pathophysiological (ie, csf, serum, genetic and autoimmune findings) and therapeutic (immunomodulation/anti-inflammatory and antibiotics treatments in association with both psychotropic and cognitive-behavioral therapies) aspects of the syndrome. The conference aims to share the knowledge on pans between experts and intends to stimulate new research hypothesis and to facilitate practitioners with the disease management.